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The most commontherapeutic techniques used for children are psychodynamic (play therapy),ego-supportive, behavioral and cognitive-behavioral, interpersonal (social skills),and family systems. Largerdefects require additional tissue in the form of local or regional flaps, or skin grafting

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A number of fMRI studies in patients withclinically diagnosed AD have identified reduced BOLDactivations in hippocampal and parahippocampalregions, compared with control subjects during epi-sodic encoding tasks (Small et al., 1999; Rombouts et al.,2000; Machulda et al., 2003; Sperling et al., 2003).